Search on: COMPLEMENT C4B 
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Descriptor English:   Complement C4b 
Descriptor Spanish:   complemento C4b 
Descriptor Portuguese:   Complemento C4b 
Synonyms English:   C4b Complement
C4b, Complement
Complement 4b
Complement Component 4b
Complement, C4b
Component 4b, Complement  
Tree Number:   D12.776.124.486.274.350.260
Definition English:   The large fragment formed when COMPLEMENT C4 is cleaved by COMPLEMENT C1S. The membrane-bound C4b binds COMPLEMENT C2A, a SERINE PROTEASE, to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE). 
Pharmacological Action:   Immunologic Factors
 
History Note English:   2006 (1990) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   24579 
Unique Identifier:   D015935 

Occurrence in VHL:
 

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